Functionalized Cyclobutenes via Multicomponent Thermal [2 + 2] Cycloaddition Reactions

Functionalized cyclobutenes via multicomponent thermal [2 + 2] cycloaddition reactions.

[reaction: see text] Enamine [2 + 2] cycloadditions can be achieved in useful yields simply by stirring a mixture of an aldehyde, diethylamine, a dialkyl fumarate, and potassium carbonate in acetonitrile at 25 degrees C, conditions that are compatible with the presence of a potential leaving group on the beta-position of the intermediate enamine. Methylation and elimination of the product cyclo...

Recent progress in cobalt-mediated [2 + 2 + 2] cycloaddition reactions.

For many years, our research group has been interested in the new developments of cobalt-mediated cyclizations. In this article, our recent achievements in the field of inter- and intramolecular [2 + 2 + 2] cyclizations are compiled.

Synthesis of Phosphorus Derivatives via Multicomponent Reactions

Stable derivatives of oxaphosphaphenanthrenes were prepared using multicomponent reactions of 3-bromo-2-naphthol, dialkyl acetylenedicarboxylate and trimethyl or triphenyl phosphite under microwave conditions with good yields. 

Enantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C2 Symmetric Digold Catalysts

The enantioselective intermolecular gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes has been achieved using non-C2-chiral Josiphos digold(I) complexes as catalysts, by the formation of the monocationic complex. This new approach has been applied to the enantioselective total synthesis of rumphellaone A.

synthesis of phosphorus derivatives via multicomponent reactions